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  • Kruspig, Björn (Institutet för miljömedicin / Institute of Environmental Medicine, 2014-12-17)
    Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority ...
  • Colzani, Edoardo (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-12-17)
    The overall survival of breast cancer patients has increased quite remarkably in the past decades in the developed countries due to substantial improvements in diagnosis and treatment. As a consequence, the proportion of ...
  • Honek, Jennifer (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2014-12-17)
    Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under ...
  • Akçakaya, Pınar (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-12-16)
    Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...
  • Meisgen, Florian (Inst för medicin, Solna / Dept of Medicine, Solna, 2014-12-16)
    The skin protects the organism from the environment and shields it from the constant danger of infections by microorganisms. Keratinocytes are epithelial cells in the skin that constitute a physical barrier towards the ...