Karolinska Institutet Open Archive
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Exploring T cell mediated immunotherapy against therapy resistant leukemic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-19)The cancer stem cell (CSC) model suggests that cancers depend on continuous replenishment from rare and distinct CSCs, but their existence has been challenging to prove for many malignancies. The CSCs in myeloid ... -
Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ... -
Infections, antibiotics, tobacco, genetic factors and risk of lada : latent autoimmune diabetes in adults, and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-17)Diabetes is a spectrum of chronic diseases characterized by hyperglycaemia. The aetiology and pathogenesis differ between types of diabetes, but all can lead to severe complications. Latent autoimmune diabetes in adults ... -
Immediate skin-to-skin contact after a very preterm birth : supporting the parent-infant relationship
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-16)Background: Preterm birth poses challenges that may negatively affect parental mental health and infant development. A well-functioning parent-infant relationship can mitigate the risk of preterm birth on infant development, ...