RSS submission
 

Collections

Recent submissions

  • Defining human adaptive immune gene diversity 

    Narang, Sanjana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-02-15)
    The lymphocytes (B and T cells) of the adaptive immune system undergo variable (V), diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen receptor repertoires capable of recognizing a ...
  • Targeting immune and desmoplastic tumor microenvironment to sensitize gynecological cancer cells to therapy 

    Gultekin, Okan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-01-02)
    Cancer is a pervasive global threat that manifests with diverse clinical attributes and notable mortality rates, particularly attributable to its metastatic potential in solid cancers. These tumours encompass various types ...
  • Therapeutic and prognostic strategies in neuroblastoma : exploring nuclear hormone receptors, MYC targets, and DIAPH3 

    Yuan, Ye (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-12-21)
    Neuroblastoma (NB) is a pediatric cancer derived from the cells of neural crest origin that form the sympathoadrenal system. Typically, the tumor cells migrate along the spinal cord and spread to the chest, neck, and/or ...
  • Charting genomic heterogeneity in tumours : from bulk to single cell 

    Harbers, Luuk (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-12-06)
    Tumours do not consist of a single homogeneous population but are complex heterogeneous systems that contain billions of ever-evolving cells with no two tumours being the same. Tumour heterogeneity is present at three ...
  • Impact of commonly prescribed drugs on the risk of colorectal cancer 

    Liu, Qing (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-11-23)
    Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for ...
  • B cell regulation in autoimmune disease 

    Wang, Shan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-11-13)
    Our immune system protects us from both foreign antigens and self-derived autoantigens by sophisticated regulation. During an immune response, the innate and adaptive parts of the immune system closely collaborate at ...
  • Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis 

    Liao, Zehuan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-11-13)
    The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the ...
  • Microenvironmental control of malignant growth 

    Bozoky, Benedek (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-10-18)
    The tumor microenvironment (TME) comprises a complex milieu of different cell types, including cancer associated fibroblasts (CAFs) and immune cells, blood vessels, and the extracellular matrix. Through its interaction ...
  • Exploring the interplay between mRNA degradation and ribosome dynamics using high-throughput sequencing 

    Zhang, Yujie (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-09-11)
    Regulation of gene expression in response to fluctuating environments is essential for cellular survival. This regulation is multi-faceted, with mRNA abundance determined by both synthesis and decay. mRNA decay regulates ...
  • Investigating novel mechanisms for transcriptional memory using genetic engineering 

    Pareja Sanchez, Yerma (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-08-01)
    Transcriptional memory is phenomenon that has gained interest due to its potential impact on human health. With our work, we wanted to contribute to the understanding of its regulation. To do so, we performed genome-wide ...
  • Perks and considerations when targeting functional non-coding regions with CRISPR/Cas9 

    Geng, Keyi (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-05-12)
    Since the CRISPR system was discovered as an adaptive immune response in prokaryotic cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as one of the most efficient and powerful molecular ...
  • Molecular epidemiology of acute respiratory virus infections 

    Dyrdak, Robert (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-05-10)
    Acute respiratory virus infections are very common but can also cause severe disease. In my thesis, I have analysed the molecular epidemiology of acute respiratory virus infections caused by enterovirus D68 and ...
  • Exploring the therapeutic effects of p53 modulation in cancer and immune cell biology 

    Ingelshed, Katrine (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-04-26)
    The tumor suppressor protein p53 is dysregulated in almost all cancer. In around 50% of cancer p53 retains wild type activity but its inactivation by the E3 ligase MDM2 in a heterodimer complex with MDMX may be amplified, ...
  • Immunoglobulin gene usage and affinity maturation in antiviral antibodies 

    Pushparaj, Pradeepa (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-04-18)
    The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of ...
  • Flame nanoengineering of antibiofilm surfaces for medical implants 

    Geissel, Felix J. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-04-13)
    Infection of bone implants is a major problem in the Healthcare sector today. Over the last years it has started to become more problematic due to biofilm formation and increasing antimicrobial resistance (AMR). A biofilm ...
  • Methods, tools, and computational environment for network-based analysis of biological data 

    Petrov, Iurii (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-02-27)
    Cancer currently affects more than 18 million persons world-wide annually. It is a leading cause of death and so far, only 60% cure rate can be reached within the most developed health care systems. The nature of cancer ...
  • Genetic and functional analysis of the adaptive immune response 

    Mandolesi, Marco (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-02-01)
    The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta ...
  • Hybrid antibacterial microneedle patches against skin infections 

    Ziesmer, Jill (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-01-20)
    Skin and soft tissue infections (SSTIs) are a major healthcare burden that has increased in incidence since the beginning of the 21st century resulting in an annual spending of approximately 15 b$ in 2012 in the United ...
  • Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis 

    Liu, Ruining (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-12-21)
    Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. Two main reasons for this are that (Bacille Calmette–Guérin) BCG, the ...
  • Targeting stromal components in the tumor microenvironment for cancer therapy 

    Wu, Jieyu (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-12-20)
    In the tumor microenvironment (TME), different cell components crosstalk with each other through various growth factors, cytokines, chemokines, and enzymes. They offered crucial survival signals for tumor cell proliferation ...

View more