Inst för neurovetenskap / Dept of Neuroscience: Recent submissions
Now showing items 1-20 of 294
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Molecular and functional organization of the locomotor networks : from brainstem to spinal cord
(Inst för neurovetenskap / Dept of Neuroscience, 2024-04-30)Locomotion is a complex behavior that allows us to move and interact with the surroundings. In mammals, descending locomotor commands from the brainstem act directly onto spinal locomotor circuits to initiate or halt ... -
Neurocomputational modelling of human decision making and volition : from neural mechanisms to behavioral outcomes
(Inst för neurovetenskap / Dept of Neuroscience, 2024-04-30)In today's world, amidst the bombardment of information, the mental health and well-being of a society with higher level of responsibility hinge on a central issue related to decision making and human agency. The essence ... -
Organic electronics and microphysiological systems to interface, monitor, and model biology
(Inst för neurovetenskap / Dept of Neuroscience, 2024-02-06)Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand ... -
Epigenetic and bioelectronic tools to study neural stem cells in health and disease
(Inst för neurovetenskap / Dept of Neuroscience, 2023-11-10)Brain development is a highly controlled, complex, and dynamic process. The mechanisms of its control need to accommodate the constantly changing contexts which, overtime, support the emergence of new neural structures ... -
On learning in mice and machines : continuous population codes in natural and artificial neural networks
(Inst för neurovetenskap / Dept of Neuroscience, 2023-10-30)Neural networks, whether artificial in a computer or natural in the brain, could represent information either using discrete symbols or continuous vector spaces. In this thesis, I explore how neural networks can represent ... -
Mechanisms of motor and non-motor complications in experimental parkinsonism
(Inst för neurovetenskap / Dept of Neuroscience, 2023-10-02)Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is classically characterized by the progressive loss of midbrain dopaminergic neurons and by the emergence of cardinal motor symptoms including ... -
Mitigating neuroinflammation : new potential therapeutics and targets
(Inst för neurovetenskap / Dept of Neuroscience, 2023-05-29)Neurodegenerative disorders, from chronic diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) to more acute injuries such traumatic brain injury (TBI), present a particular challenge to public health ... -
On striatum in silico
(Inst för neurovetenskap / Dept of Neuroscience, 2023-05-22)The basal ganglia are a collection of subcortical nuclei involved in movement and action selection. The striatum is the main input nucleus with extensive projections from the cortex and thalamus, and dopaminergic projections ... -
Body perception and brain plasticity in blind and sighted individuals
(Inst för neurovetenskap / Dept of Neuroscience, 2023-04-28)Lack of vision is associated with large-scale brain plasticity. Vision, touch, proprioception, interoception, and other sensory modalities are thought to play a vital role in developing and maintaining bodily awareness. ... -
Novel fluorescent tools and techniques for 3D imaging of the cleared brain
(Inst för neurovetenskap / Dept of Neuroscience, 2023-02-23)Background: To better understand the complexity of the brain and how it becomes impaired under different pathological states, a considerably large number of brains would be needed for imaging to generate highly detailed ... -
Multiple circuits controlling the versatility of locomotion : molecular and connectivity principles in zebrafish
(Inst för neurovetenskap / Dept of Neuroscience, 2022-11-24)Locomotion is produced by neuronal circuits in the spinal cord. These motor circuits rely on the activation of supraspinal centres and transform descending excitatory drive into coordinated rhythmic activity. Far from ... -
The molecular basis of spiral ganglion neurons : diversity and development
(Inst för neurovetenskap / Dept of Neuroscience, 2022-10-03)Hearing, one of our main senses, allows us to socialize, listen and enjoy sounds around us. The critical transmitters of the sound information are the spiral ganglion neurons (SGNs); located in the cochlea, they transmit ... -
Alterations in circadian entrainment : translational value in major depression
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-09)Adverse conditions of different origin occurring during development can have a negative impact on the nervous system and increase risk for the onset of mental disorders. In mice prenatal exposure to excess glucocorticoids ... -
Visuo-thermal congruency modulates the sense of body ownership
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-08)Thermosensation has been redefined as an interoceptive modality that provides information about the homeostatic state of the body. However, the contribution of thermosensory signals to the sense of body ownership remains ... -
Limits of cross-modal plasticity? Short-term visual deprivation does not enhance cardiac interoception, thermosensation, or tactile spatial acuity
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-08)In the present study, we investigated the effect of short-term visual deprivation on discriminative touch, cardiac interoception, and thermosensation by asking 64 healthy volunteers to perform four behavioral tasks. The ... -
Editorial : When the body feels like mine : constructing and deconstructing the sense of body ownership through the lifespan
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-08) -
Interoception as independent cardiac, thermosensory, nociceptive, and affective touch perceptual submodalities
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-08)Interoception includes signals from inner organs and thin afferents in the skin, providing information about the body’s physiological state. However, the functional relationships between interoceptive submodalities are ... -
The role of the skin in interoception : a neglected organ?
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-08)In the past two decades, interoception has received increasing attention in the fields of psychology and cognitive science, as well as neuroscience and physiology. A plethora of studies adopted the perception of cardiac ... -
Principles of regional covariance in brain structure
(Inst för neurovetenskap / Dept of Neuroscience, 2022-08-31)The human brain varies between individuals in both shape and size. These variations are not unique for each brain region. This causes grey matter density between regions to covary, a phenomenon known as “structural brain ... -
Escaping the riptide : probing the malleability of cognition
(Inst för neurovetenskap / Dept of Neuroscience, 2022-05-25)Cognitive abilities are essential for functioning in daily life – even something as mundane as going to the grocery store taps into a variety of cognitive functions. Exactly how and under what circumstances they can be ...