Doktorsavhandlingar / Doctoral Theses - C6 (IMM): Recent submissions
Now showing items 1-20 of 319
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Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Diet, genetic susceptibility, latent autoimmune diabetes in adults, type 1 and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-03)Diabetes is one of the most common chronic diseases, yet our understanding of modifiable risk factors remains incomplete. This project aimed to elucidate the role of diet in the risk of latent autoimmune diabetes in adults ... -
Exposures through drinking water and risk of chronic disease
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-02)Drinking water is the most important constituent of our diet. Yet, the importance of drinking water quality for population health is understudied. The overall aim of this thesis was to increase this knowledge by examining ... -
Exploring allergic and irritant contact dermatitis : biomarkers, mechanisms, and allergen uptake
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-30)Contact dermatitis (CD) is a common disease resulting from direct skin contact with allergens or irritants and greatly affects the life quality of suffering individuals. It is categorized into two main forms, namely allergic ... -
Health consequences of gender-based harassment at work
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-25)Background: Experiences at work with gender-based violence and harassment (GBVH) from superiors, co-workers or third parties are common. This includes a range of verbal or physical behaviors that can be of a sexual nature ... -
Infections, antibiotics, tobacco, genetic factors and risk of lada : latent autoimmune diabetes in adults, and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-17)Diabetes is a spectrum of chronic diseases characterized by hyperglycaemia. The aetiology and pathogenesis differ between types of diabetes, but all can lead to severe complications. Latent autoimmune diabetes in adults ... -
The role of inflammatory cells in sarcoidosis and asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-02)Immuno-homeostasis refers to maintaining a delicate balance between immune responses and tolerance. It relies on the harmonious interplay of various inflammatory cells, including macrophages, monocytes, dendritic cells, T ... -
Modifiable risk factors, blood proteins, and venous thromboembolism
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-01-09)Venous thromboembolism (VTE) refers to blood clots in the veins, which is an underappreciated vascular disease that can cause disability and mortality. Although some triggers for VTE (e.g., surgery, fracture, infection, ... -
Congenital heart disease, genetic syndromes, and childhood cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-12-27)Childhood cancer is a diverse group of rare diseases and remains a significant global concern, despite substantial improvements in survival outcomes. Yet, little is known about its etiology. Certain congenital disorders, ... -
Studies on the molecular and functional properties of exosomes in the metastatic prostate cancer bone microenvironment
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-11-20)Prostate cancer is the most common cancer type and the second leading cancer related cause of death worldwide in men. Prostate cancer patients initially respond to standard treatment (e.g., hormonal, surgery/irradiation) ... -
T cell responses in amyotrophic lateral sclerosis : friends or foes?
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-07-19)Amyotrophic lateral sclerosis (ALS) is an idiopathic fatal neurodegenerative disease that is characterized by the loss of upper and lower motor neurons. Inflammation is widely recognized as a hallmark of this disease; ... -
Occupational exposure to particles in relation to chronic obstructive pulmonary disease and cardiovascular disease
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-03-01)Objective: The working life is expanding with increased retirement ages as the population is aging, in Sweden but in also other parts of the world. However, workers with poor health might not cope with working in higher ... -
Persistent environmental pollutants and risk of cardiovascular disease
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-02-27)Persistent chemicals emitted in the environment can have a considerable impact on ecosystems and human health, now and in the future. One notorious group of persistent organic pollutants (POPs) is the per- and polyfluoroalkyl ... -
Environmental exposures and cardiac arrhythmias
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-01-04)Cardiac arrhythmias lead to substantial mortality and morbidity world-wide. The most severe form of cardiac arrhythmia, cardiac arrest, is one of the leading causes of death in Europe and North America. Further, the ... -
Evaluating occupational health interventions : design, implementation, and effects
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-12-22)Background: Poor mental health, e.g. stress, anxiety, and depression, in the workplace is a challenge worldwide due to the individual suffering and its impact on sickness absence and productivity loss, causing societal ... -
Psychological distress and breast cancer : a bidirectional link
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-11-09)Psychological distress is one of the six vital signs among patients with cancer. An increased risk of psychiatric disorders has also been reported among cancer patients, compared with the general population. On the other ... -
Physical workload and exit from the labour market : epidemiological studies with a focus on employees with musculoskeletal disorders
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-10-28)Background: The length of working life is expanding in the light of the ageing population. In response, countries including Sweden are increasing the retirement age. However, many workers, especially workers with heavy ... -
Mental disorders as risk factors, comorbidities, and consequences of cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-09-06)Cancer and mental disorders are both heterogenous groups of diseases and with substantial public health burden. Accumulating evidence has supported an elevated risk of mental disorders among patients with cancer. Different ... -
The effect of spinal manipulative therapy on heart rate variability and pain in patients with persistent or recurrent neck pain
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-07-26)OBJECTIVE: Persistent or recurrent neck pain is a common reason to seek healthcare. Manual therapy in combination with exercises is recommended by clinical guidelines for this patient group. Autonomic dysregulation with ... -
Early-life metal exposure and child growth and development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-24)Cadmium, lead and arsenic are toxic metals, the exposure to which occurs primarily through food and drinking water. While many studies are available about their health effects in adults, studies in children and adolescents ...