Inst för laboratoriemedicin / Dept of Laboratory Medicine: Recent submissions
Now showing items 1-20 of 469
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Advancements in detection of performance enhancing drugs in dried blood spots : focusing on erythropoietin
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-26)The use of erythropoietin (EPO) for performance enhancing purposes is detected mainly in urine and serum samples in anti-doping laboratories. However, dried blood spots (DBS) have emerged as a potential additional sample ... -
In search of therapeutic candidates for tandem repeat disorders
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-04)Triplet-repeat disorders, including Friedreich's Ataxia (FRDA) and Huntington's disease (HD), are genetic conditions characterized by the expansion of specific trinucleotide sequences within affected genes. In FRDA, the ... -
Improvement of microbiological diagnostics in sepsis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-03-27)Sepsis, a life-threatening condition characterized by a dysregulated host response to infection, poses significant diagnostic and therapeutic challenges, contributing to high morbidity and mortality rates worldwide. The ... -
Enhancing the efficiency of viral and non-viral gene delivery vectors
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-02-13)Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. ... -
Pathophysiological role and therapeutic potential of extracellular vesicles in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-01-04)Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are endogenously generated through various biogenesis pathways within most cellular entities. Subsequently, they are released into the extracellular ... -
Aerobic exercise capacity in chronic kidney disease
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-11-14)Aerobic exercise capacity is impaired in chronic kidney disease (CKD) and it is associated with increased mortality and reduced quality of life. The mechanisms underlying reduced exercise capacity in CKD are complex and ... -
Harnessing T cell immunity for the prevention and treatment of liver cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-11-10)Hepatocellular carcinoma (HCC) accounts for more than 80% of all diagnosed cases of liver cancer which is a major cause of cancer related fatalities worldwide. With few improvements in the survival rates during the last ... -
The role of mechanical loading, sex and TRAP/ACP5 on bone properties
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-07-26)A well-balanced bone structure involves a balanced role of the osteoclasts, osteoblasts, and osteocytes. The balance is maintained by different internal and external factors like calcium demands, the immune system and ... -
An integrative systems biology study to understand immune aging in people living with HIV
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-05-10)Antiretroviral therapy (ART) reduces viral replication, restores T helper cells and improves the survival of people living with HIV (PWH), transforming a life-threatening disease into a manageable chronic infection. ... -
Pharmacovigilance of mass drug administration for the control of schistosomiasis and soil transmitted helminths in Rwanda
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-04-24)Preventive chemotherapy (PC) is a WHO recommended core interventional measure or a strategy to prevent, control and eliminate STH and schistosomiasis as public health burden by 2030. Though preventable and treatable, they ... -
Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-03-30)In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo ... -
Effects of anti-inflammatory drugs on human skeletal muscle adaptations to resistance training
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-03-15)Previous studies in young adults suggest that non-steroidal anti-inflammatory drugs (NSAIDs) may impair early skeletal muscle responses to exercise. Whether chronic use of NSAIDs affects skeletal muscle adaptations to ... -
Home-cage monitoring of activity patterns of laboratory mice
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-03-09)The mouse, deriving from the house mouse, is the most common species used in biomedical research, and offers great advantages for researchers to study gene functions in a complex living organism. However, using animals as ... -
Interfering with interferons : interplay between SARS-CoV-2 and interferon response
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-02-27)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, which has been an ongoing global health crisis. At the beginning of the pandemic, all the efforts were ... -
Identification of genes and pathways involved in the development and progression of glomerular diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-02-22)Chronic kidney disease (CKD) affects millions of people worldwide and is characterized by a reduction in glomerular filtration rate and albuminuria resulting in a gradual loss of kidney function. The high prevalence of the ... -
A novel prophylactic strategy to minimize stem cell transplantation-related complications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-02-08)Hematopoietic stem cell transplantation (HSCT) is a curative treatment and sometimes is the only option for patients with hematological malignancies and some types of solid tumors. It is also the first-line treatment for ... -
Blood volume expansion following supramaximal exercise : occurrence and contribution to maximal oxygen uptake
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2023-01-04)Previously published research using various types of exercise has shown that central hemodynamic factors such as blood volume (BV) and maximal cardiac output (Qmax) are of large importance in the mediation of improvements ... -
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-12-06)Extracellular vesicles (EVs) can be functionalized to display specific protein receptors on their surface. However, surface-display technology typically labels only a small fraction of the EV population. Here, we show that ... -
Pharmacovigilance capacity in East Africa with focus on neglected tropical diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-11-17)Pharmacovigilance aims to enhance patient safety in relation to the use of medicines by reducing the incidence and severity of adverse events which includes supporting public health programs by providing information on the ... -
Extremely drug resistant E. coli and K. pneumoniae : novel approaches against their spread and related infections
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-10-27)Antibiotic resistance in Enterobacteriaceae is a well-established hindrance and the spread of pathogenic high-risk clones harboring extended-spectrum -lactamases (ESBLs) and carbapenemases is posing a global health ...