Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions

Now showing items 21-40 of 349

    • Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells 

      Karvouni, Maria (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-25)
      Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival ...

    • Characterizing the effects of weight loss on human adipose tissue gene transcription and cell composition 

      Tseng, Ben Tzu-Pin (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-05)
      Obesity is a globally prevalent metabolic disease that affects more than one billion people according to the World Health Organization and the number continues to increase. Obesity has detrimental effects on health and ...

    • Cell shape determines gene expression in cardiomyocytes 

      Haftbaradaran Esfahani, Payam (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-04)
      The fundamental biological processes involve sensing biophysical stress, strain and forces along with conversion of these stimuli into chemical signals. These processes are linked to the atrophic and hypertrophic responses. ...

    • Improving NK cell-based immunotherapy of cancer by exploration of migration and inhibitory receptor-ligand interactions 

      Segerberg, Filip (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-03)
      The possibility to utilize the immune system as a mean to target malignantly transformed cells has emerged as a novel treatment modality during the last decades and is a field that is under rapid development. Natural ...

    • Human innate lymphoid cell trafficking and function in vivo 

      Alisjahbana, Arlisa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-04-14)
      Human organs and tissues, such as the lung, are composed of various spatially distinct anatomical compartments. Each compartment represents a different tissue environment within the organ, performs specific functions and ...

    • Magnetic resonance imaging as a tool for diagnosis, evaluation, and prognosis in patients with primary sclerosing cholangitis 

      Grigoriadis, Aristeidis (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-01-24)
      Primary sclerosing cholangitis (PSC) is a chronic liver and bile duct disease of unknown etiology. It usually progresses to liver failure and need for liver transplantation. Additionally, patients with PSC have an increased ...

    • Understanding the heterogeneity of the hematopoietic stem cells 

      Somuncular, Ece (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-11-25)
      The hematopoietic system is replenished and maintained throughout life by rare hematopoietic stem cells (HSCs) that reside in the bone marrow (BM) of adult mammals. Over the last 20 years, the advancement in the field lead ...

    • Innate lymphocyte responses in inflammatory diseases 

      Emgård, Johanna (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-31)
      The immune system is a highly sophisticated system that has evolved to protect the host from external and internal threats. However, under some circumstances the immune response can get dysregulated and cause inflammatory ...

    • Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology 

      Leijonhufvud, Caroline (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-21)
      Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing ...

    • Liver cirrhosis : epidemiology, prognosis, and cancer 

      Bengtsson, Bonnie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-29)
      Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC). Patients with liver cirrhosis also have a high risk to develop infections leading to deterioration of liver function and increased mortality. In ...

    • Innate lymphoid cell differentiation and functions in intestinal homeostasis and disease 

      Kokkinou, Efthymia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-15)
      The gastrointestinal (GI) tract, which includes the small and the large intestine, is considered the largest immunological organ that plays a pivotal role in food digestion, nutrient absorption and fuel generation. ...

    • Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure 

      De Genst, Erwin; Foo, Kylie S; Xiao, Yao; Rohner, Eduarde; de Vries, Emma; Sohlmér, Jesper; Witman, Nevin; Hidalgo, Alejandro; Kolstad, Terje R S; Louch, William E; Pehrsson, Susanne; Park, Andrew; Ikeda, Yasuhiro; Li, Xidan; Mayr, Lorenz M; Wickson, Kate; Jennbacken, Karin; Hansson, Kenny; Fritsche-Danielson, Regina; Hunt, James; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-19)
      The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. ...

    • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy 

      Beverborg, Niels Grote; Spater, Daniela; Knoll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Sillje, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmer, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)
      Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...

    • An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation 

      Rohner, Eduarde; Witman, Nevin; Sohlmér, Jesper; De Genst, Erwin; Louch, William E; Sahara, Makoto; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)
      Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ...

    • Clinical aspects of hidradenitis suppurativa 

      Killasli, Hassan (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-12)
      Hidradenitis suppurativa (HS) is often a chronic skin disease of unknown etiology characterized by formation of non-infectious inflammatory nodules, abscesses, and suppurating skin tunnels mainly in axillae and groins. The ...

    • The role of innate immunity in obesity-induced tissue inflammation 

      Stiglund, Natalie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-02)
      The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the ...

    • Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors 

      Poch, Christine M; Foo, Kylie S; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Bähr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymiuk, Nikolai; Lu, Kun; Tomasi, Roland; Dendorfer, Andreas; Gaspari, Marco; Parrotta, Elvira; Cuda, Giovanni; Krane, Markus; Sinnecker, Daniel; Hoppmann, Petra; Kupatt, Christian; Fritsche-Danielson, Regina; Moretti, Alessandra; Chien, Kenneth R; Laugwitz, Karl-Ludwig (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-02)
      Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft ...

    • Origin and ontogeny of human lung macrophages 

      Evren, Elza (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-20)
      The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. The lungs are ...

    • Implications of chronic kidney disease on presentation, treatment and outcomes in patients with aortic stenosis 

      Vavilis, Georgios (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-19)
      Background: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world. No pharmacological treatment has been proved to halt the progression to severe disease and after symptom debut, the ...

    • Aspects of diagnosis, prognosis and treatment of nonalcoholic fatty liver disease 

      Holmer, Magnus (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-16)
      Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally. NAFLD is caused by obesity, often in combination with type 2 diabetes mellitus (T2D). Lifestyle modifications that lead to weight ...