Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 21-40 of 329
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Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-25)Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival ... -
Cell shape determines gene expression in cardiomyocytes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-04)The fundamental biological processes involve sensing biophysical stress, strain and forces along with conversion of these stimuli into chemical signals. These processes are linked to the atrophic and hypertrophic responses. ... -
Improving NK cell-based immunotherapy of cancer by exploration of migration and inhibitory receptor-ligand interactions
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-03)The possibility to utilize the immune system as a mean to target malignantly transformed cells has emerged as a novel treatment modality during the last decades and is a field that is under rapid development. Natural ... -
Human innate lymphoid cell trafficking and function in vivo
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-04-14)Human organs and tissues, such as the lung, are composed of various spatially distinct anatomical compartments. Each compartment represents a different tissue environment within the organ, performs specific functions and ... -
Magnetic resonance imaging as a tool for diagnosis, evaluation, and prognosis in patients with primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-01-24)Primary sclerosing cholangitis (PSC) is a chronic liver and bile duct disease of unknown etiology. It usually progresses to liver failure and need for liver transplantation. Additionally, patients with PSC have an increased ... -
Understanding the heterogeneity of the hematopoietic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-11-25)The hematopoietic system is replenished and maintained throughout life by rare hematopoietic stem cells (HSCs) that reside in the bone marrow (BM) of adult mammals. Over the last 20 years, the advancement in the field lead ... -
Innate lymphocyte responses in inflammatory diseases
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-31)The immune system is a highly sophisticated system that has evolved to protect the host from external and internal threats. However, under some circumstances the immune response can get dysregulated and cause inflammatory ... -
Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-21)Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing ... -
Liver cirrhosis : epidemiology, prognosis, and cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-29)Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC). Patients with liver cirrhosis also have a high risk to develop infections leading to deterioration of liver function and increased mortality. In ... -
Innate lymphoid cell differentiation and functions in intestinal homeostasis and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-15)The gastrointestinal (GI) tract, which includes the small and the large intestine, is considered the largest immunological organ that plays a pivotal role in food digestion, nutrient absorption and fuel generation. ... -
Clinical aspects of hidradenitis suppurativa
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-12)Hidradenitis suppurativa (HS) is often a chronic skin disease of unknown etiology characterized by formation of non-infectious inflammatory nodules, abscesses, and suppurating skin tunnels mainly in axillae and groins. The ... -
The role of innate immunity in obesity-induced tissue inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-02)The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the ... -
Origin and ontogeny of human lung macrophages
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-20)The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. The lungs are ... -
Implications of chronic kidney disease on presentation, treatment and outcomes in patients with aortic stenosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-19)Background: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world. No pharmacological treatment has been proved to halt the progression to severe disease and after symptom debut, the ... -
Aspects of diagnosis, prognosis and treatment of nonalcoholic fatty liver disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-16)Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally. NAFLD is caused by obesity, often in combination with type 2 diabetes mellitus (T2D). Lifestyle modifications that lead to weight ... -
Characterization and targeting of leukemia propagating cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-09)Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. Many ... -
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-13)Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ... -
Maternal obesity and offspring metabolic outcomes : focus on sex differences
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-01)Obesity is a worldwide health issue affecting all ages and both sexes, and its prevalence is progressively increasing among adults and children. The predisposition to metabolic complications caused by obesity is sex ... -
B cell responses to human flavivirus vaccination and SARS-CoV-2 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-02-25)Viral infections pose a major threat to global heath. As specific antiviral treatments are lacking against many human viruses, vaccination is the most effective medical intervention to prevent severe disease and death. ... -
Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ...