Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery: Recent submissions
Now showing items 21-40 of 639
-
Prostate cancer : investigating diagnosis, treatment and outcomes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-19)Background: Prostate cancer is difficult to study. The prostate is located so that it is hard to palpate and because of the dense pelvic bones it is hard to visualize using radiology such as computed tomography. The prostate ... -
The bicuspid aortic valve and thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-14)About 1% of the population is born with an aortic valve composed of only two cusps, called a bicuspid aortic valve. Bicuspid aortic valve is associated with a high risk of both aortic valve disease and ascending aortic ... -
Studies on the acute porphyrias : with special reference to women’s health
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-01)The acute porphyrias are a group of rare inherited disorders of the metabolism of heme. Three acute porphyrias comprise most of the cases: acute intermittent porphyria (AIP), hereditary coproporphyria (HCP) and variegate ... -
Central nervous system malformations and epilepsy in children : genetic, imaging, and clinical aspects
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-31)Malformations of cortical development frequently lead to neurodevelopmental disabilities and epilepsy in children. Nevertheless, comprehensive prevalence data based on population studies are scarce. The objective of this ... -
The role of T-type calcium channels in human pancreatic β cell maturity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-27)This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets ... -
Complex genomic rearrangements in rare brain disorders : genetic architecture and molecular consequences
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-23)Structural variants (SVs) within the genome, such as deletions, duplications, inversions, and translocations, are common but underappreciated causes of rare diseases. Complex genomic rearrangements involving two or more ... -
Severe COVID-19 and routine biomarker patterns
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-10)In acute infectious diseases, the composition of the blood changes. That includes proteins, blood cells and smaller solutes. Routine blood tests have a fundamental role in the diagnosis and follow-up of patients with ... -
Cardiovascular disease and health anxiety in patients with differentiated thyroid cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-22)Background Differentiated thyroid cancer (DTC) accounts for over 90% of all thyroid malignancies, and is typically treated with a total thyroidectomy and radioactive iodine (RAI) to eliminate both macro- and microscopic ... -
Liquid biopsies in pediatric oncology : towards clinical implementation
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-06)During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies ... -
The anterior chamber of the eye as an islet transplantation site in type-2 diabetes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-08-31)Diabetes mellitus is a chronic disease, one of the leading causes of death and a consistent financial burden globally. It occurs when insulin is insufficient for glucose homeostasis. Pancreatic islet transplantation drew ... -
Depression and delirium in cardiac surgery patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-04)Depression is common in persons with cardiac disease, and there is a well-known association between depression and increased cardiovascular morbidity and mortality. Preoperative depression has been associated with ... -
Studies of congenital genetic aberrations behind childhood leukemia
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-03)Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, ... -
Rare complications in cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-28)Background: Curative cancer surgery aims to reduce mortality and morbidity related symptoms caused by the cancer. The surgery is often done at a time when the patient is presenting lesser or no symptoms and at a time when ... -
Pelvic fractures : epidemiology and treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-20)The epidemiology of pelvic and acetabular fractures has been sparsely described and up-to date information on incidence, demographic distributions and treatment are lacking. Surgical treatment of pelvic and acetabular ... -
Long-term follow-up after surgery for chronic thromboembolic pulmonary hypertension
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-12)Background: Pulmonary endarterectomy (PEA) is the treatment recommended for all operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this thesis was to evaluate long-term survival, quality ... -
Biomechanical and morphological aspects of abdominal aortic aneurysm growth and rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-05)Abdominal aortic aneurysms (AAAs) are dilatations of the abdominal aorta that pose a risk of rupture. The only effective treatment is intervention prior to rupture, but this is also associated with mortality and morbidity. ... -
Abdominal aortic aneurysms : sex and gender disparities in surveillance, treatment and outcome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-03-07)Background: In the field of abdominal aortic aneurysm (AAA), a lot of what is unknown converge in two specific topics: untreated patients and women. Best management strategies related to surveillance, treatment and outcome ... -
The male predominance in oesophageal adenocarcinoma and the role of sex hormones
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-28)Oesophageal adenocarcinoma is a subtype of oesophageal cancer with rapidly rising incidence over the last decades. This rise in incidence is strongest in western countries and more among men than in women, with a male ... -
Paediatric surgery in Uganda : burden of disease and barriers to quality of care
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-15)Background: In recent years there has been an increased awareness of surgical conditions within global health. A special emphasis is needed for children which constitute a large proportion of the populations in many ... -
Novel biomarkers in regulating human dense connective tissue repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-18)Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the ...