Doktorsavhandlingar / Doctoral Theses - K1 (MMK): Recent submissions
Now showing items 21-40 of 543
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Severe COVID-19 and routine biomarker patterns
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-10)In acute infectious diseases, the composition of the blood changes. That includes proteins, blood cells and smaller solutes. Routine blood tests have a fundamental role in the diagnosis and follow-up of patients with ... -
Cardiovascular disease and health anxiety in patients with differentiated thyroid cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-22)Background Differentiated thyroid cancer (DTC) accounts for over 90% of all thyroid malignancies, and is typically treated with a total thyroidectomy and radioactive iodine (RAI) to eliminate both macro- and microscopic ... -
Liquid biopsies in pediatric oncology : towards clinical implementation
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-06)During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies ... -
The anterior chamber of the eye as an islet transplantation site in type-2 diabetes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-08-31)Diabetes mellitus is a chronic disease, one of the leading causes of death and a consistent financial burden globally. It occurs when insulin is insufficient for glucose homeostasis. Pancreatic islet transplantation drew ... -
Depression and delirium in cardiac surgery patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-04)Depression is common in persons with cardiac disease, and there is a well-known association between depression and increased cardiovascular morbidity and mortality. Preoperative depression has been associated with ... -
Studies of congenital genetic aberrations behind childhood leukemia
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-03)Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, ... -
Rare complications in cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-28)Background: Curative cancer surgery aims to reduce mortality and morbidity related symptoms caused by the cancer. The surgery is often done at a time when the patient is presenting lesser or no symptoms and at a time when ... -
Pelvic fractures : epidemiology and treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-20)The epidemiology of pelvic and acetabular fractures has been sparsely described and up-to date information on incidence, demographic distributions and treatment are lacking. Surgical treatment of pelvic and acetabular ... -
Long-term follow-up after surgery for chronic thromboembolic pulmonary hypertension
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-12)Background: Pulmonary endarterectomy (PEA) is the treatment recommended for all operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this thesis was to evaluate long-term survival, quality ... -
Biomechanical and morphological aspects of abdominal aortic aneurysm growth and rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-05)Abdominal aortic aneurysms (AAAs) are dilatations of the abdominal aorta that pose a risk of rupture. The only effective treatment is intervention prior to rupture, but this is also associated with mortality and morbidity. ... -
Abdominal aortic aneurysms : sex and gender disparities in surveillance, treatment and outcome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-03-07)Background: In the field of abdominal aortic aneurysm (AAA), a lot of what is unknown converge in two specific topics: untreated patients and women. Best management strategies related to surveillance, treatment and outcome ... -
The male predominance in oesophageal adenocarcinoma and the role of sex hormones
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-28)Oesophageal adenocarcinoma is a subtype of oesophageal cancer with rapidly rising incidence over the last decades. This rise in incidence is strongest in western countries and more among men than in women, with a male ... -
Paediatric surgery in Uganda : burden of disease and barriers to quality of care
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-15)Background: In recent years there has been an increased awareness of surgical conditions within global health. A special emphasis is needed for children which constitute a large proportion of the populations in many ... -
Novel biomarkers in regulating human dense connective tissue repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-18)Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the ... -
A multidisciplinary long-term evaluation of patients born with unilateral cleft lip and palate treated with different surgical protocols
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-11)Introduction and aims: The aim of this project was to evaluate the long-term outcome after the multidisciplinary treatment of young adults born with unilateral cleft lip and palate (UCLP) regarding speech and communicative ... -
Bicycle trauma and it‘s consequences
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-09)The popularity to ride a bicycle is increasing worldwide and significant political efforts are made to promote cycling. To bike to work is generally seen as a health-conscious and environment friendly way of commuting. ... -
Outcomes of surgery for oesophageal cancer with focus on fatigue
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-31)Oesophageal cancer is the 6th leading cause of cancer mortality globally. Extensive surgery (oesophagectomy) with neoadjuvant chemo(radio)therapy is the backbone of curative treatment for oesophageal cancer. The thesis ... -
Adverse effects of treatment for rectal cancer : sexual function, hormones, and bone health
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-20)Thanks to improved outcomes from multimodal rectal cancer (RC) treatment, long-term survival is increasing; thus, focus on the long-term adverse effects of treatment is required. This thesis aimed to increase knowledge ... -
The role of proprotein convertases in vascular disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-18)To date, the role of the proprotein convertase subtilisin/kexin (PCSK) family in vascular disease is largely unknown, with the exception of PCSK9 and its key function in lipid metabolism. The PCSK family constitutes of 9 ... -
Towards an improved survival in gastric cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-14)Gastric cancer is a globally important contributor to morbidity and mortality from cancer. The age-standardised incidence has declined during the last decades, but the total incidence has not due to an aging population. ...