EC Funded Resources Set
Recent submissions
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The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-30)Phosphorylation of receptor tyrosine kinases (RTKs) has a key role in cellular functions contributing to the malignant phenotype of tumor cells. We and others have previously demonstrated that RTK ROR1 is overexpressed in ... -
Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-gamma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-07-25)Natural killer (NK) cells are innate lymphocytes that are able to directly kill tumor cells through different mechanisms including ligation of TNF-related apoptosis-inducing ligand (TRAIL) receptors. Zoledronic acid (ZA) ... -
Doxorubicin sensitizes human tumor cells to NK and T cell-mediated killing by augmented TRAIL-receptor signaling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-07-25)Doxorubicin (DOX) is an anthracycline antibiotic that is widely used to treat different types of malignancy. In this study, it was studied whether DOX could be used to render tumor cells susceptible to apoptosis by NK and ... -
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-22)The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of ...