Artiklar / Articles - K1 (MMK)
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Recent submissions
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Wearable neuromuscular electrical stimulation on quadriceps muscle can increase venous flow
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase peak venous velocity ... -
Residual substance P levels after capsaicin treatment correlate with tendon repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)The aim of the study was to assess healing after capsaicin-induced SP depletion during rat Achilles tendon repair by biomechanical testing. Capsaicin treatment reduced the concentrations of substance P (SP) by ~60% ... -
Prolonged immobilization compromises up-regulation of repair genes after tendon rupture in a rat model
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)It was hypothesized that mobilization versus immobilization after injury would promote tissue healing by regulating gene expression for molecules associated with repair. Cast immobilization versus free mobilization was ... -
High plantar force loading after Achilles tendon rupture repair with early functional mobilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Background: Mechanical loading is essential for tendon healing and may explain variability in patient outcomes after Achilles tendon rupture (ATR) repair. However, there is no consensus regarding the optimal postoperative ... -
Knee extensor force production and discomfort during neuromuscular electrical stimulation of quadriceps with and without gluteal muscle co-stimulation
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Purpose: To investigate whether Neuromuscular Electrical Stimulation (NMES) simultaneously applied on the quadriceps (Q) and gluteal (G) muscles, as compared to single Q-stimulation alters the knee extensor force production ... -
The effect of neuromuscular electrical stimulation on the human skeletal muscle transcriptome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Aim: The influence on acute skeletal muscle transcriptomics of neuromuscular electrical stimulation (NMES), as compared to established exercises, is poorly understood. We aimed to investigate the effects on global ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Prediction of individuals at high absolute risk of esophageal squamous cell carcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)Background and Aims: This study aimed to develop a prediction model for identifying individuals at high absolute risk of esophageal squamous cell carcinoma (ESCC) for endoscopic screening at a curable stage based on readily ... -
Global time trends in the incidence of esophageal squamous cell carcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)Background & Aims: Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer worldwide (90%). We aimed to provide an update of the global temporal trends in the incidence of ... -
Association between levels of sex hormones and risk of esophageal adenocarcinoma and Barrett’s esophagus
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)Background & Aims: Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that regulate levels of sex hormones associated with ... -
Association between metformin use and risk of esophageal squamous cell carcinoma in a population-based cohort study
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-11)Objectives: Esophageal cancer is a highly fatal malignant neoplasm, with two etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal ... -
Cardiac remodeling in aortic and mitral valve disease : a simulation study with clinical validation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-03)Background: Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we ... -
Ageing, deep vein thrombosis and male gender predict poor outcome after acute Achilles tendon rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)Background: Patients with acute Achilles tendon rupture (ATR) exhibit prolonged healing, high incidence of deep venous thrombosis (DVT) and a wide variation of functional outcome. This extensive discrepancy in outcome may ... -
Reduced time to surgery improves patient-reported outcome after achilles tendon rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)Background: Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols, however, ... -
Prognosis following cancer surgery during holiday periods
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-19)Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long-term prognosis than for non-holiday periods. ... -
Weekday of cancer surgery in relation to prognosis
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced ... -
Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia gastric ... -
Recurrence of reflux after laparoscopic antireflux surgery : reply
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09) -
Nordic registry-based cohort studies : possibilities and pitfalls when combining Nordic registry data
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)Aims: All five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have nationwide registries with similar data structure and validity, as well as personal identity numbers enabling linkage between registries. ... -
Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...