LifeGene : a large prospective population-based study of global relevance
Author: Almqvist, Catarina; Adami, Hans-Olov; Franks, Paul W; Groop, Leif; Ingelsson, Erik; Kere, Juha; Lissner, Lauren; Litton, Jan-Eric; Maeurer, Markus; Michaëlsson, Karl; Palmgren, Juni; Pershagen, Göran; Ploner, Alexander; Sullivan, Patrick F; Tybring, Gunnel; Pedersen, Nancy L
Department: Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics
View/ Open:
Author Accepted Manuscript (1.996Mb)
Abstract
Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enroll 500,000 Swedes and follow them longitudinally for at least 20 years.
Institution:
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
- Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
- Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University Hospital Sweden, Umeå, Sweden
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Lund University, Malmö, Sweden
- Department of Clinical Sciences, Diabetes and Endocrinology Unit, Lund University, Lund, Sweden
- Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
- Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
- Swedish Institute for Infectious Disease Control, Stockholm, Sweden
- Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
- Department of Mathematical Statistics, Stockholm University, Stockholm, Sweden
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Citation: Eur J Epidemiol. 2011 Jan;26(1):67-77.
Citation DOI: 10.1007/s10654-010-9521-x
Citation PMID: 21104112
Citation ISI: 000286104700009
Publishing journal: European Journal of Epidemiology
Eprint status: Peer Reviewed
Version: Accepted
Issue date: 2013-09-25
Sponsorship:
- Karolinska Institutet
- Stockholm County Council
- Swedish Research Council
- Torsten and Ragnar Söderbergs Foundation
- AFA Försäkringar
Rights:
Article is made available in accordance with the publisher's policy and may be subject to copyright law. Please refer to the publisher's site for terms of use.
Publication year: 2011
Statistics
Total Visits
Views | |
---|---|
LifeGene ...(legacy) | 798 |
LifeGene ... | 240 |
Total Visits Per Month
November 2023 | December 2023 | January 2024 | February 2024 | March 2024 | April 2024 | May 2024 | |
---|---|---|---|---|---|---|---|
LifeGene ... | 9 | 8 | 6 | 0 | 4 | 4 | 4 |
File Visits
Views | |
---|---|
LifeGene_manuscript.pdf(legacy) | 511 |
LifeGene_manuscript.pdf | 332 |
AAM_LifeGene.pdf | 12 |
LifeGene_manuscript_revision.doc(legacy) | 1 |
Top country views
Views | |
---|---|
United States | 496 |
Sweden | 118 |
China | 79 |
Germany | 56 |
Russia | 21 |
South Korea | 12 |
Finland | 9 |
Ireland | 9 |
Canada | 7 |
Denmark | 6 |
Top cities views
Views | |
---|---|
Ashburn | 111 |
Sunnyvale | 46 |
Stockholm | 37 |
Kiez | 22 |
Romeo | 18 |
Beijing | 17 |
Shenzhen | 12 |
Seoul | 11 |
Dublin | 8 |
Norrköping | 7 |