Artiklar / Articles - H7 (MedH)
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Recent submissions
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Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-19)The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. ... -
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ... -
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ... -
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-02)Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ... -
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-17)A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ... -
Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-02-17)The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart ... -
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ... -
Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-02-15)Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ... -
Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-05)Background: Idiopathic scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide ... -
Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-07-31)Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies. ... -
Analysis of colorectal cancer morpohology in relation to sex, location and family history
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2013-02-13)Background: Studies of colorectal cancer (CRC) have suggested different mechanisms of carcinogenesis in men and women, young and old patients, right- and left sided tumors, and sporadic and familial tumors. These differences ...