Maternal asthma and early fetal growth : the MAESTRO study
Author: Rejnö, Gustaf; Lundholm, Cecilia; Saltvedt, Sissel; Larsson, Kjell; Almqvist, Catarina
Department: Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics
View/ Open:
Version of Record (566.1Kb)
Abstract
Background: Several maternal conditions can affect fetal growth, and asthma during pregnancy is known to be associated with lower birth weight and shorter gestational age.
Objective: In a new Swedish cohort study on maternal asthma exposure and stress during pregnancy (MAESTRO), we have assessed if there is evidence of early fetal growth restriction in asthmatic women or if a growth restriction might come later during pregnancy.
Methods: We recruited women from eight antenatal clinics in Stockholm, Sweden. Questionnaires on background factors, asthma status and stress were assessed during pregnancy. The participants were asked to consent to collection of medical records including ultrasound measures during pregnancy, and linkage to national health registers. In women with and without asthma, we studied reduced or increased growth by comparing the second-trimester ultrasound with first-trimester estimation. We defined reduced growth as estimated days below the 10th percentile and increased growth as days above the 90th percentile. At birth, the weight and length of the newborn and the gestational age was compared between women with and without asthma.
Results: We enrolled 1693 participants in early pregnancy and collected data on deliveries and ultrasound scans in 1580 pregnancies, of which 18% of the mothers had asthma. No statistically significant reduced or increased growth between different measurement points were found when women with and without asthma were compared; adjusted odds ratios for reduced growth between first and second trimester 1.11 95% CI (0.63–1.95) and increased growth 1.09 95% CI (0.68–1.77).
Conclusion and clinical relevance: In conclusion, we could not find evidence sup- porting an influence of maternal asthma on early fetal growth in the present cohort. Although the relatively small sample size, which may enhance the risk of a type II error, it is concluded that a potential difference is likely to be very small.
Objective: In a new Swedish cohort study on maternal asthma exposure and stress during pregnancy (MAESTRO), we have assessed if there is evidence of early fetal growth restriction in asthmatic women or if a growth restriction might come later during pregnancy.
Methods: We recruited women from eight antenatal clinics in Stockholm, Sweden. Questionnaires on background factors, asthma status and stress were assessed during pregnancy. The participants were asked to consent to collection of medical records including ultrasound measures during pregnancy, and linkage to national health registers. In women with and without asthma, we studied reduced or increased growth by comparing the second-trimester ultrasound with first-trimester estimation. We defined reduced growth as estimated days below the 10th percentile and increased growth as days above the 90th percentile. At birth, the weight and length of the newborn and the gestational age was compared between women with and without asthma.
Results: We enrolled 1693 participants in early pregnancy and collected data on deliveries and ultrasound scans in 1580 pregnancies, of which 18% of the mothers had asthma. No statistically significant reduced or increased growth between different measurement points were found when women with and without asthma were compared; adjusted odds ratios for reduced growth between first and second trimester 1.11 95% CI (0.63–1.95) and increased growth 1.09 95% CI (0.68–1.77).
Conclusion and clinical relevance: In conclusion, we could not find evidence sup- porting an influence of maternal asthma on early fetal growth in the present cohort. Although the relatively small sample size, which may enhance the risk of a type II error, it is concluded that a potential difference is likely to be very small.
Institution:
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Obstetrics and Gynaecology Unit, Södersjukhuset, Stockholm, Sweden
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
- Obstetrics & Gynaecology Unit, Karolinska University Hospital, Stockholm, Sweden
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
Citation: Clin Exp Allergy. 2021 Jul;51(7):883-891.
Citation DOI: 10.1111/cea.13864
Citation PMID: 33705581
Citation ISI: 000632676400001
Publishing journal: Clinical and Experimental Allergy
Eprint status: Peer Reviewed
Version: Published
Issue date: 2023-02-08
Sponsorship:
- Swedish Research Council, 2018-02640
- The Strategic Research Program in Epidemiology at Karolinska Institutet
- Hjärt-Lungfonden
- Stockholms County Council (ALF-projects)
- Swedish Initiative for research on Microdata in the Social And Medical Sciences (SIMSAM), 340-2013-5867
Rights:
CC BY 4.0
Publication year: 2021
Statistics
Total Visits
Views | |
---|---|
Maternal ... | 138 |
Total Visits Per Month
November 2023 | December 2023 | January 2024 | February 2024 | March 2024 | April 2024 | May 2024 | |
---|---|---|---|---|---|---|---|
Maternal ... | 8 | 19 | 5 | 6 | 8 | 1 | 3 |
File Visits
Views | |
---|---|
Maternal_asthma_and_early_fetal_growth-the_MAESTRO_study.pdf | 59 |
Top country views
Views | |
---|---|
United States | 39 |
Sweden | 30 |
South Korea | 14 |
Ireland | 10 |
China | 7 |
Germany | 7 |
Romania | 5 |
Canada | 3 |
India | 2 |
Japan | 2 |
Top cities views
Views | |
---|---|
Norrköping | 8 |
Ashburn | 7 |
Dublin | 7 |
Washington | 5 |
Seattle | 4 |
Eskilstuna | 3 |
Hangzhou | 3 |
San Mateo | 3 |
Andover | 2 |
Bromma | 2 |